Name Surname:
Begüm Kocatürk
Title:
Assoc.Prof.
Department:
Basic Oncology
Contact:
(312) 305 44 09
2008 yılında Bilkent Üniversitesi Moleküler Biyoloji ve Genetik Bölümü’nden başarı bursu kazanarak yüksek şeref listesinde mezun olmuştur. Doktorasını Hollanda Leiden Üniversitesi’nde tamamlamış ve pıhtılaşma faktörlerinin meme kanseri gelişiminde etkilerini araştırmıştır. Çalışmalarına doktora sonrası araştırmacı olarak Bilkent Üniversitesi UNAM’da devam etmiş ve Endoplazmik Retikulum Stresin ateroskleroz gelişimindeki etkilerini incelemiştir. Fulbright doktora sonrası araştırmacı bursunu kazanarak Cedars Sinai Tıp Merkezi’nde Kawasaki vaskülitinin etiyolojisini anlamak adına çalışmalarda bulunmuştur. 2020 yılından beri Hacettepe Üniversitesi Temel Onkoloji Anabilim Dalı’nda öğretim üyesi olarak görev yapmaktadır.
• Noval RM, Kocatürk B, Franklin BS, Arditi M: Platelets in Kawasaki disease: mediators of vascular inflammation. Nat Rev Rheumatol 2024.
• Kocatürk B, Ozmen F, Arditi M, Ozen S: Editorial: Recent advances in pediatric inflammatory diseases. Front Pediatr 2023;11:1237625.
• Kocatürk B, Lee Y, Nosaka N, Abe M, Martinon D, Lane ME, Moreira D, Chen S, Fishbein MC, Porritt RA, Franklin BS, Noval RM, Arditi M: Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight 2023;8.
• Kroone C*, Tieken C*, Kocatürk B*, Paauwe M, Blok EJ, Unlu B, van den Berg YW, Stanganello E, Kapteijn MY, Swier N, Zhang X, Duits DEM, Lin Y, Oostenbrink LVE, van den Akker RFP, Mosnier LO, Hawinkels LJ, van Vlijmen BJM, Ruf W, Kuppen PJ, Cannegieter SC, Buijs JT, Versteeg HH: Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer. Blood Adv 2023;7:2388-2400.
*Eşit katkıyı ifade eder
• Kocatürk B: In silico analysis reveals PRDX4 as a prognostic and oncogenic marker in renal papillary cell carcinoma. Gene 2023;859:147201.
• Kocatürk B: Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis. Cancer Med 2023;12:3830-3844.
• Unlu B, Kocatürk B, Rondon AMR, Lewis CS, Swier N, van den Akker RFP, Krijgsman D, Noordhoek I, Blok EJ, Bogdanov VY, Ruf W, Kuppen PJK, Versteeg HH: Integrin regulation by tissue factor promotes cancer stemness and metastatic dissemination in breast cancer. Oncogene 2022;41:5176-5185.
• Kocatürk B, Balık Z, Pişiren G, Kalyoncu U, Özmen F and Özen S : Spondyloarthritides: Theories and beyond. Front. Pediatr 2022 10:1074239.
• Kocatürk B: Bioinformatic Analysis of Expression Pattern and Prognostic Value of Oxidoreductase ERO1L in Pancreatic Cancer. Acta Medica 2022; 53(3): 233-244.
• Marek-Iannucci S, Yildirim AD, Hamid SM, Ozdemir AB, Gomez AC, Kocatürk B, Porritt RA, Fishbein MC, Iwawaki T, Noval RM, Erbay E, Arditi M: Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis. JCI Insight 2022;7.
• Maruyama D*, Kocatürk B*, Lee Y, Abe M, Lane M, Moreira D, Chen S, Fishbein MC, Porritt RA, Noval RM, Arditi M: MicroRNA-223 Regulates the Development of Cardiovascular Lesions in LCWE-Induced Murine Kawasaki Disease Vasculitis by Repressing the NLRP3 Inflammasome. Front Pediatr 2021;9:662953
*Eşit katkıyı ifade eder
• Hamid SM, Citir M, Terzi EM, Cimen I, Yildirim Z, Dogan AE, Kocatürk B, Onat UI, Arditi M, Weber C, Traynor-Kaplan A, Schultz C, Erbay E: Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth. EMBO Rep 2020;e51462.
• Porritt RA, Markman JL, Maruyama D, Kocatürk B, Chen S, Lehman TJA, Lee Y, Fishbein MC, Noval RM, Arditi M: Interleukin-1 Beta-Mediated Sex Differences in Kawasaki Disease Vasculitis Development and Response to Treatment. Arterioscler Thromb Vasc Biol 2020;40:802-818.
• Onat UI, Yildirim AD, Tufanli O, Cimen I, Kocatürk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J, Shah PK, Gottlieb RA, Arditi M, Erbay E: Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis. J Am Coll Cardiol 2019;73:1149-1169.
• Tufanli O, Telkoparan AP, Acosta-Alvear D, Kocatürk B, Onat UI, Hamid SM, Cimen I, Walter P, Weber C, Erbay E: Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A 2017;114:E1395-E1404.
• Cimen I, Kocatürk B, Koyuncu S, Tufanli O, Onat UI, Yildirim AD, Apaydin O, Demirsoy S, Aykut ZG, Nguyen UT, Watkins SM, Hotamisligil GS, Erbay E: Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Sci Transl Med 2016;8:358ra126.
• Kocatürk B, Tieken C, Vreeken D, Unlu B, Engels CC, de Kruijf EM, Kuppen PJ, Reitsma PH, Bogdanov VY, Versteeg HH: Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression. J Thromb Haemost 2015;13:1683-1693.
• Kocatürk B, Versteeg HH: Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth. J Vis Exp 2015.
• Kocatürk B, Versteeg HH: Tissue factor-integrin interactions in cancer and thrombosis: every Jack has his Jill. J Thromb Haemost 2013;11 Suppl 1:285-293.
• Kocatürk B, Van den Berg YW, Tieken C, Mieog JS, de Kruijf EM, Engels CC, van der Ent MA, Kuppen PJ, Van de Velde CJ, Ruf W, Reitsma PH, Osanto S, Liefers GJ, Bogdanov VY, Versteeg HH: Alternatively spliced tissue factor promotes breast cancer growth in a beta1 integrin-dependent manner. Proc Natl Acad Sci U S A 2013;110:11517-11522.
• Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VY: Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. Int J Cancer 2014;134:9-20.
• Kocatürk B, Versteeg HH: Tissue factor isoforms in cancer and coagulation: may the best isoform win. Thromb Res 2012;129 Suppl 1:S69-S75.
• van den Hengel LG, Kocatürk B, Reitsma PH, Ruf W, Versteeg HH: Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor. Blood 2011;118:3446-3448.
Organel Biyolojisi, Protein Homeostazı, Endoplazmik Retikulum Stres, Proteazom
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| Foreign Experience / Education | Hollanda Leiden Üniversitesi, Cedars Sinai Tıp Merkezi |
: (312) 305 44 09
: bkocaturk@hacettepe.edu.tr


